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Susanna Rosi, Ph.D.

Susanna Rosi, Ph.D.

Principal Investigator, Altos Labs, Bay Area Institute

Born and raised under the Tuscan sun Susanna Rosi is a founding Principal Investigator at Altos Labs and Adjunct Professor in the Departments of Physical Therapy Rehabilitation Science and Neurological Surgery at the University of California San Francisco. Susanna did her undergraduate and graduate studies at the University of Florence in the department of Clinical and Preclinical Pharmacology studying inflammation, aging, and Alzheimer’s disease. She then moved from Tuscany to Tucson to complete post doc at the University of Arizona in the Neural System Memory and Aging, she started early her academic career at UCSF at the age of 30. She quicky raised to the professor rank and become the Lewis and Ruth Cozen Chair Professor in the Departments of Physical Therapy Rehabilitation Science and Neurological Surgery at UCSF where she was faculty for 16 years before leaving for Altos labs where she is one of the founding principal investigators. Her work is focused on understanding mechanisms responsible for the cognitive dysfunctions observed in the context of ageing, traumatic brain injuries, and neurodegenerative states. Her work demonstrated that brain injury induced cognitive dysfunction can be reversed by resetting dysfunctional microglia. Susanna’s Team made the amazing discovery that aging related cognitive dysfunction and long-lasting dementia after TBI can be reversed by briefly inhibiting the integrated stress response (ISR) pharmacologically. She has been the recipient of several NCI, NIA, NINDS awards, she has been a NASA investigator for over 10 years and the recipient of the 2021 J.W. Osborne Award for “fundamental discovery on normal tissue radiation responses” from the Radiation Research Society.

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